Salvestrin 1& 2

Salvesterols are undoubtedly one of the most important anti-cancer and anti-aging compounds yet discovered. As an anti-cancer agent, Salvesterols help to block many reactions associated with cancer.  Salvestrols are unique because it battles cancer in all three phases of the cancer process: initiation, promotion, and progression. Animal studies have shown that Salvesterols significantly reduced the occurrence of skin tumors in the presence of several carcinogenic compounds.

There is a naturally existing link in common fruits, vegetables and herbs that is known to reverse and prevent cancer and heart disease. Salvesterol is that natural protective agent produced by plants when they are subject to stressful circumstances, such as, cold weather, insects, fungal attacks, and lack of nutrients. Research indicates there is a great protective value obtained by animals and humans that consume foods high in natural Salvesterols.

Why so much Cancer ?

Cancer continues unabated because we are exposed to a multitude of toxic chemicals and our modern diet of processed food fails to provide the protection needed. Modern foods lack the nutrients needed for cancer protection that once existed in mankind's daily diet.

The genes that stimulate cancer growth reside in every normal cell of our bodies. Cells constantly undergo mutation from exposure to toxic chemicals that we eat and breath. Once triggered Cancer cells grow wildly to become a malignant tumor. Scientists know of about one hundred different types of oncogenes, some of which take part in the long, slow progression to cancer when the tissues undergo prolonged stress. Unending stress, for example, is recognized by science as a source of cellular mutation.

When a person with a healthy immune system develops cancer cells, the body will deal with and dispose of mutant cells on a regular basis.  Cancer develops in the out-of-balance organism. Cancer cells create a protective shell around themselves (the cytochrome P450 enzyme, CYP1B1) which prevents the immune system from destroying them. 

Pancreatin is an enzyme normally secreted by the pancreas. The level of this enzyme has been found to be severely deficient in cancer patients. The pancreatic enzyme is one of the body's natural defenses against cancer.  Pancreatin serves to strip the protective enzyme from the mutant cancer cells, allowing the immune system to attack and destroy the cell.  Salvesterol is similar but has a secondary benefit as it is able to penetrate the barrier, then metamorphoses to become a deadly poison against the same cancer cell it has come in contact with.

The Salvesterols in Natural Edge's Salvestrin act as a protease inhibitor and slow down the late stages of cancer progression in a way similar to chemotherapy, but in a non-toxic fashion. Moreover as an antioxidant it counteracts the super-charged free radicals that ordinarily damage normal cells.  Salvestrin as a protease inhibitor blocks or reverses DNA damage within normal cells to stop them from mutating into a malignancy.

In March of 2002, the research of Professor Gerry Potter, demonstrated the cancer inhibiting benefits that Salvesterols can provide. Salvesterols when in contact with the enzyme CYP1B1 (which is only found in cancer tumors) cause a metabolic reaction to occur, and the powerful antileukaemic agent piceatannol is produced. Piceatannol is a cancer cell destroyer. Salvesterols are only active against cancer cells; they are very selective and non-toxic to healthy cells.

Professor Potter has described Salvesterols as ‘a wolf in sheep’s clothing’. It is likely that we have discovered a mechanism that can tackle cancer cells whether they are formed or forming. Salvesterols because they require enzymatic activation are known or described as a pro-drug, with the ability to avoid the serious side-effects of most commonly used, anti-cancer drugs that often severely damage normal tissue as well as in some cases rendering the user infertile.

The cytochrome P450 enzyme, CYP1B1, is common to a wide array of cancer cells (leukemia, lymphoma, tumors of the brain, breast, prostate, lung, colon, stomach, kidney, etc.) and is not present in healthy tissue. The recent discovery of a new class of molecule (Salvesterols), and its important activity in removing diseased cells from the human body, are being reviewed. Salvesterols are non-toxic until activated by the CYP1B1 enzyme to induce apoptosis (death) in diseased cells. Tumor selectivity and the bioavailability of Salvesterols, and the implications of their discovery for treatment of disease, have been examined in detail.

Gerry Potter, B.SC., Ph.D.. Professor of Medicinal Chemistry, and Director of the Cancer Drug Discovery Group in the Leicester School of Pharmacy at De Montford University, England.

Magnolol induces apoptosis in human leukemia cells via cytochrome c release and caspase activation.

Graduate Institute of Physiology, College of Medicine, National Taiwan University, Taipei, Taiwan.

Magnolol, was found to prevent proliferation of human HL-60 cells and Jurkat T leukemia cells via inducing cancer cell death. By contrast, Magnolol did not cause cell death in normal healthy cells. Polymerase was found during cell deaths induced by magnolol. In addition, both pan-caspase and selective caspase-9 inhibitor blocked magnolol-induced cell death. The cell death could also be partially attenuated by caspase-3 and -2 inhibitors. Magnolol induced the reduction of mitochondrial transmembrane potential and the release of cytochrome c into cytoplasm. In conclusion, our findings indicate that magnolol-induced apoptotic signaling is carried out through mitochondria alternations to caspase-9 and that then the downstream effector caspases are activated sequentially.

As you can see Salvestrin has a wide range of health benefits to offer. Our Salvestrin product formulation is comprised of Salvesterol and other synergistic natural herbs that have proven their effectiveness for hundreds of years. Salvesterols are the powerhouse ingredient in the mixture.

Animal studies demonstrate that caloric-restricted diets extend life span of test animals by as much as fifty percent. Salvesterols act as a potent anti-oxidant; it’s anti-aging properties have been recently proven to go far beyond the simple action of scavenging and eliminating harmful free radical activity.

Salvesterols show themselves to be impressive anti-inflammatory agents for neurological degeneration and dementia. Salvesterols may be particularly important as a preventative for those at risk for Alzheimer’s and Parkinson’s disease.

Salvesterols are well known for cardiovascular protective benefits of decreasing platelet aggregation, inhibiting the oxidation of LDL cholesterol, and reducing serum lipids. Salvesterols plays a major role in the cholesterol-lowering effects of red wine. Controlled clinical studies suggest that Salvesterols result in reduced risk of cardiovascular disease.

Salvesterols act as a powerful phyto-estrogen, helps maintain normal estrogen activity, reduce hot flashes, balance mood swings, and promote bone density for women with menopausal symptoms. As a phyto-estrogen Salvesterols can block the onset and progression of cancers related to estrogen dominance, such as breast cancer in women and prostate cancer in aging men. Research results demonstrate that Salvesterols have immune boosting and anti-infective properties.

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